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Effects of acute thyroxin depletion on hearing in humans
Author(s) -
Mra Zan,
Wax Mark K.
Publication year - 1999
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1097/00005537-199903000-00001
Subject(s) - medicine , audiogram , thyroidectomy , otoacoustic emission , hormone , thyroid , hearing loss , audiology , audiometry , physiology
Objective : To study the physiologic effect of acute thyroid hormone depletion on hearing and the function of outer hair cells. Design : Audiologic and otoacoustic emission testing of subjects undergoing total thyroidectomy before surgery and up to 6 weeks after surgery. Magnitude of thyroxin depletion monitored by serum thyroid‐stimulating hormone levels. Setting : Hearing research laboratory at a state university. Subjects : Ten patients undergoing total thyroidectomy. Main Outcome Measures : Detection of hearing loss on audiogram and decrease or disappearance of otoacoustic emissions as a result of acute thyroxin depletion. Results : No significant changes in the audiogram and otoacoustic emission configurations were detected, although thyroid‐stimulating hormone levels became elevated after total thyroidectomy. Conclusion : Although thyroid hormone is thought to play a role in the physiology of hearing in humans, no deleterious effects on hearing can be identified up to 6 weeks after thyroxin depletion