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Submandibular and lacrimal gland immunoglobulin in the C3H.MRL‐ Fas lpr autoimmune mouse model of sjögren's syndrome
Author(s) -
Trune Dennis R.,
Leedy Daniel A.
Publication year - 1998
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1097/00005537-199811000-00025
Subject(s) - lacrimal gland , submandibular gland , sjögren syndrome , antibody , immunoglobulin g , immunoglobulin a , lacrimal apparatus , immunology , medicine , pathology , autoimmune disease
Objective: To distinguish potential autoimmune and nonautoimmune mechanisms underlying the salivary gland inflammation seen in Sjögren's syndrome and normal aging. Study Design: Immunohistochemical studies were conducted on the lacrimal and salivary glands of 2‐ and 5‐month‐old C3H.MRL‐ Fas lpr autoimmune strain mice and age‐matched C3H/HeJ nonautoimmune controls. Methods: Glandular inflammatory foci, interstitial areas, and vasculature were stained for immunoglobulin G (IgG), immunoglobulin A (IgA), and complement to determine differences in their local immune parameter. Differences between the two strains were compared for immune changes attributable to autoimmune disease and between the two normal groups for normal aging changes. Results: Greater staining of IgG, IgA, and complement occurred in the inflammatory foci and interstitial areas of 5‐month‐old C3H.MRL‐ Fas lpr lacrimal and submandibular glands compared with 5‐month‐old controls. Normal mice showed some increased immunoglobulin staining with aging, but little or no complement in any glands. Conclusions: These differential findings suggest that the systemic autoimmune disease plays a more direct role in focal glandular inflammation in Sjögren's syndrome, whereas less severe immune mechanisms are involved in the inflammation of normal glands. Laryngoscope , 108:1729–1732, 1998