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Effect of Intratympanic Steroid Application on the Development of Experimental Cholesteatoma
Author(s) -
Sennaroglu Levent,
Özkul Ayhan,
Gedikoglu Gökhan,
Turan Ergin
Publication year - 1998
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1097/00005537-199804000-00015
Subject(s) - cholesteatoma , middle ear , prednisolone , inflammation , medicine , chinchilla , surgery , anatomy
By introducing certain irritants into the middle ear it is possible to produce cholesteatoma. Propylene glycol, the main agent used for this purpose, produces a long‐standing inflammation that causes hyperplasia and migration of the epithelium through an intact tympanic membrane. In the present investigation topical prednisolone was used in order to inhibit the production of cholesteatoma. The results indicate that there is a marked decrease in inflammation and hence experimental cholesteatoma production when prednisolone is administered into the middle ear.