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Expression of Adhesion Molecules in Nonallergic Chronic Sinusitis
Author(s) -
Shimomura Akira,
Ikeda Katsuhisa,
Suzuki Hideaki,
Nakabayashi Seiichiro,
Oshima Takeshi,
Furukawa Masayuki,
Takasaka Tomonori,
Ando Noriaki,
Ohtani Haruo,
Nagura Hiroshi
Publication year - 1997
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1097/00005537-199711000-00018
Subject(s) - cell adhesion molecule , intercellular adhesion molecule 1 , pathology , infiltration (hvac) , lamina propria , chronic sinusitis , sinusitis , eosinophil , chemokine , biology , immunology , epithelium , inflammation , medicine , asthma , physics , thermodynamics
Endothelial and epithelial adhesion molecules are important in the recruitment of leukocytes to inflammatory sites. To determine the relationship between recruited leukocytes and adhesion molecules in the paranasal sinus mucosa of nonallergic chronic sinusitis, we surgically obtained mucosa from 16 patients and identified the expression of intercellular adhesion molecules(ICAM‐1), vascular cell adhesion molecule‐1 (VCAM‐1), E‐selectin, and P‐selectin by immunohistochemistry. Neutrophils were significantly dominant in the nasal discharge as compared with eosinophils. The degree of neutrophil infiltration in the paranasal sinus mucosa was prominent in both intraepithelial and subepithelial areas as compared with the lamina propria. In each tissue site, the degree of infiltration of neutrophils was similar to that of eosinophils. These findings suggest that the tissue neutrophils actively and rapidly migrated into the lumen. All the adhesion molecules except VCAM‐1 were expressed in the vascular endothelial cells. On the other hand, the surface epithelial cells showed the expression of only ICAM‐1. The expression of ICAM‐1 on the endothelial cells correlated with the degree of neutrophil infiltration in the mucosa. The eosinophil infiltration was not dependent on any adhesion molecules examined here. It was concluded that ICAM‐1 expression in the mucosa may be involved in neutrophil recruitment and may contribute to the establishment of the inflammatory cell distribution in the paranasal sinus of nonallergic chronic sinusitis.