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Sustained Release of Antibiotic From a Fibrin‐Gelatin‐Antibiotic Mixture
Author(s) -
Park Moon Suh,
Kim Yong Bok
Publication year - 1997
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1097/00005537-199710000-00016
Subject(s) - fibrin , gentamicin , gelatin , antibiotics , bacillus subtilis , ampicillin , microbiology and biotechnology , chemistry , pharmacology , medicine , bacteria , immunology , biology , biochemistry , genetics
To improve the therapeutic effect of antibiotics in the ear cavity postoperatively, a fibrin‐ and gelatin‐based drug delivery system was designed and in vitro efficacy was evaluated. Four kinds of fibrin clot were made from ampicillin, gentamicin, and ofloxacin, and biologic assay was performed using Bacillus subtilis. The fibrin‐gelatin‐gentamicin mixture demonstrated antibiotic activity for up to 120 hours against B subtilis. Gentamicin was found to be released more slowly from the fibrin‐gelatin mixture than from the fibrin mixture in this experiment. These results suggest that this device can be clinically used in a limited field such as postoperative care of ear infection.