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Age‐related Alterations in the Auditory Brainstem Responses and the Compound Action Potentials in Guinea Pigs
Author(s) -
Nozawa Izuru,
Imamura Shunichi,
Fujimori Isao,
Hashimoto Kaori,
Shimomura Shinichi,
Hisamatsu Kenichi,
Murakami Yoshihiko
Publication year - 1996
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1097/00005537-199608000-00024
Subject(s) - brainstem , auditory brainstem response , audiology , compound muscle action potential , guinea pig , latency (audio) , electrophysiology , medicine , neuroscience , psychology , hearing loss , electrical engineering , engineering
The auditory brainstem response (ABR) and the eighth nerve compound action potential (CAP) were measured using click stimuli to investigate the agerelated alteration in the auditory function in 66 guinea pigs consisting of four age groups. With advancing age, a gradual elevation of the thresholds in both the ABR and CAP was clearly seen, together with the prolonged latencies for waves I, II, III, and IV to clicks at 95 dBpeSPL in the ABR. There were some individual differences in either threshold elevation or latency prolongation of both the ABR and CAP in aged guinea pigs. These findings suggest that the effect of individual differences on degenerative aging processes of the auditory system should be considered in selected aged animals, although a significant elevation of the neural auditory threshold is clearly found with advancing age as a whole.