Premium
Prognostic Value of EGFR and TGF‐α in Early Laryngeal Cancer Treated With Radiotherapy
Author(s) -
Wen QingHua,
Miwa Takaki,
Yoshizaki Tomokazu,
Nagayama Ikuo,
Furukawa Mitruru,
Nishijima Hiroshi
Publication year - 1996
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1097/00005537-199607000-00019
Subject(s) - epidermal growth factor receptor , medicine , transforming growth factor , radiation therapy , cancer , basal cell , laryngeal neoplasm , carcinoma , oncology , epidermal growth factor , immunohistochemistry , receptor , pathology , cancer research
The purpose of this study was to determine the overexpression of both epidermal growth factor receptor (EGFR) and transforming growth factoralpha(TGF‐α) (a ligand of EGFR) in early laryngeal squamous cell carcinoma. In addition, we attempted to evaluate the prognostic values of our findings. Expression of EGFR and TGF‐α in tumor tissue was examined immunohistochemically in 68 patients who had been treated with radiotherapy for early laryngeal cancer. Overexpression of the two factors was noted in 42.6% and 55.9%, respectively. No significant differences due to age, tumor size, and location or grade of cancer tissues were seen. Higher survival rates, found in patients with EGFR (‐) and TGF‐α (‐) tumors as compared with those with EGFR (+) and TGF‐α (+) (97.4%, 100% and 86.2%, 86.8%, respectively), were not statistically significant. The recurrence rates were similar between EGFR (+) and EGFR (‐) (37.9% and 35.9%, respectively). However, the recurrence rate in patients with TGF‐α (+) was significantly higher (57.9%) than in those with TGF‐α (‐) (10%; P <.01). Therefore overexpression of TGF‐α may be an important indicator for recurrence in patients with early laryngeal squamous cell carcinoma treated by irradiation. Laryngoscope, 106:884‐885, 1996