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Epithelial Cell Proliferation in Nasal Polyps Could Be Up‐Regulated by Platelet‐Derived Growth Factor
Author(s) -
Coste André,
Wang QiuPing,
RoudotThoraval Françoise,
Chapelin Catherine,
Bedbeder Philippe,
Poron Françoise,
Peynègre Roger,
Escudier Estelle
Publication year - 1996
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1097/00005537-199605000-00011
Subject(s) - proliferating cell nuclear antigen , platelet derived growth factor receptor , platelet derived growth factor , lamina propria , growth factor , cell growth , nasal polyps , immunohistochemistry , epithelium , pathology , proliferation marker , connective tissue , biology , microbiology and biotechnology , cancer research , immunology , medicine , receptor , biochemistry
The modifications of epithelial differentiation and proliferation observed in nasal polyps (NP) could be related to local secretion of growth factors, among which platelet‐derived growth factor (PDGF) could play a key role. We therefore prospectively studied, by immunohistochemistry, proliferating cell nuclear antigen (PCNA, an S‐phase cell marker), PDGF, and CD‐68 (activated macrophages marker) expression in NP and inferior turbinate mucosa (NM) in 11 patients. Our data show that PCNA and PDGF expression are increased in NP epithelium, while CD‐68 expression is increased in NP epithelium and lamina propria when compared to NM. Increased local PDGF secretion by numerous activated macrophages could therefore be involved in epithelial cell proliferation up‐regulation in NP. PDGF could also be involved in the pathogenesis of NP via its connective tissue remodeling actions. Laryngoscope, 106:578‐583, 1996