Open AccessA Potential Role for Endothelin-1 in Peripheral Vascular Disease
Author(s) -
Michael R. Dashwood,
Anita Jagroop,
Diana A. Gorog,
Peder J. Bagger
Publication year - 2000
Publication title -
journal of cardiovascular pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.762
H-Index - 100
eISSN - 1533-4023
pISSN - 0160-2446
DOI - 10.1097/00005344-200036051-00030
Subject(s) - vasa vasorum , tunica media , peripheral , endothelin receptor , receptor , vascular disease , medicine , femoral artery , anatomy , endothelin 1 , pathology , immunohistochemistry , arterial disease , smooth muscle
The distribution of endothelin-1 (ET-1) and its receptors (ET(A)/ET(B)) has been studied in segments of femoral artery obtained from patients undergoing operation for peripheral vascular disease (PVD) using a combination of immunohistochemistry and autoradiography. Both receptor subtypes were located on the tunica media of vessel segments, with ET(A)-receptors predominating. Densitometric analysis showed that there was no difference in receptor binding to proximal/distal arterial segments from PVD patients. High-resolution autoradiography identified ET(B) binding to vascular nerves and vasa vasorum, mainly in distal portions of femoral arteries. Immunoreactive ET-1 was also identified that was associated with the vasa vasorum.