Open AccessEndothelin-1 in the Heart During Exercise
Author(s) -
Seiji Maeda,
Takashi Miyauchi,
Satoshi Sakai,
Tsutomu Kobayashi,
Katsutoshi Goto,
Yasuro Sugishita,
Mitsuo Matsuda
Publication year - 1998
Publication title -
journal of cardiovascular pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.762
H-Index - 100
eISSN - 1533-4023
pISSN - 0160-2446
DOI - 10.1097/00005344-199800001-00112
Subject(s) - chronotropic , inotrope , medicine , heart rate , endothelin 1 , endocrinology , endothelin receptor , cardiac function curve , cardiology , physical exercise , cardiac output , heart failure , hemodynamics , receptor , blood pressure
In addition to its potent vasocontractile effects, endothelin-1 (ET-1) has potent positive inotropic and chronotropic effects on isolated heart muscles in vitro. However, it is not known whether the production of ET-1 in the heart is altered by exercise. In this study we investigated the production of ET-1 in the heart during exercise. Rats performed treadmill running of 45-min duration. Sedentary rats served as controls. Immediately after exercise, the heart was quickly removed. The peptide level of ET-1 in the heart was measured by a sandwich-enzyme immunoassay. The peptide level of ET-1 in the heart was significantly higher in the exercise group than in the control sedentary group. Therefore, we have demonstrated that production of ET-1 in the heart is increased by exercise. The present study suggests that myocardial ET-1 participates in the modulation of cardiac function during exercise.