Open AccessHyperpermeability of Abdominal Capillary Vessels to Endothelin-1 in Patients with Diabetes Mellitus
Author(s) -
Tomio Nakayama,
Yukiko Numata,
Masui Kawada,
Hisayo Kurokawa,
Toshihiro Nakamura,
Kohzo Hashimoto
Publication year - 1993
Publication title -
journal of cardiovascular pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.762
H-Index - 100
eISSN - 1533-4023
pISSN - 0160-2446
DOI - 10.1097/00005344-199322008-00094
Subject(s) - medicine , diabetes mellitus , diabetic nephropathy , peritoneal dialysis , continuous ambulatory peritoneal dialysis , endothelin receptor , peritoneal fluid , nephropathy , urology , pathophysiology , endothelin 1 , gastroenterology , endocrinology , receptor
To elucidate the pathophysiologic significance of circulating endothelin-1 (ET-1) to the vascular lesions in diabetic patients, ET-1 levels in plasma and peritoneal dialysis fluid were measured in 11 patients receiving continuous ambulatory peritoneal dialysis (CAPD) [five with diabetic nephropathy (group A); six with chronic renal failure without diabetes mellitus (group B)]. ET-1 levels were determined by a highly sensitive and specific enzymeimmunoassay. Plasma ET-1 levels in group A were not significantly different from those in group B (3.3 +/- 0.9 versus 3.5 +/- 0.9 pg/ml). However, the amounts of ET-1 in peritoneal dialysis fluid in group A were significantly greater than those in group B (19.2 +/- 13.2 versus 10.4 +/- 6.3 ng/day). These results suggest that abdominal capillary vessels in diabetic patients are hyperpermeable to ET-1.