Open AccessIs Urodilatin (Rather Than Atriopeptin) the Primary Natriuretic Peptide of the ANP Family?
Author(s) -
K. L. Goetz
Publication year - 1993
Publication title -
journal of cardiovascular pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.762
H-Index - 100
eISSN - 1533-4023
pISSN - 0160-2446
DOI - 10.1097/00005344-199322002-00027
Subject(s) - excretion , medicine , endocrinology , atrial natriuretic peptide , urine , sodium , natriuretic peptide , urine sodium , npr2 , chemistry , heart failure , organic chemistry
This article summarizes evidence supporting the hypothesis that urodilatin, rather than atriopeptin, is the member of the atrial natriuretic peptide family primarily involved in the regulation of renal sodium excretion. A number of lines of evidence imply that atriopeptin is only of trivial importance in the regulation of sodium excretion during normal living conditions. On the other hand, urodilatin, which is produced in the kidneys, has properties very similar to atriopeptin. Moreover, its excretion in the urine appears to correlate quite closely with the concomitant excretion of sodium.