Open AccessAmiodarone Interaction with Lidocaine
Author(s) -
Joachim B. Siegmund,
John H. Wilson,
Thomas Imhoff
Publication year - 1993
Publication title -
journal of cardiovascular pharmacology
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.762
H-Index - 100
eISSN - 1533-4023
pISSN - 0160-2446
DOI - 10.1097/00005344-199304000-00001
Subject(s) - amiodarone , lidocaine , toxicity , drug interaction , medicine , antiarrhythmic agent , pharmacology , anesthesia , drug , atrial fibrillation , heart disease
We report a case of lidocaine toxicity with seizures that appears to represent a drug interaction with amiodarone. A toxic lidocaine level and reduced lidocaine clearance were documented 65 h after amiodarone was added to the treatment regimen. This is the first report of increased levels and serious clinical toxicity of lidocaine due to amiodarone. The mechanism appears to be altered hepatic metabolism of lidocaine caused by amiodarone.