Open AccessDifferential Role of Brain Ascending Noradrenergic Bundles in the Circulatory Effects of α-Methyldopa and Clonidine
Author(s) -
Maarten van den Buuse,
Geoffrey A. Head,
Paul Körner
Publication year - 1993
Publication title -
journal of cardiovascular pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.762
H-Index - 100
eISSN - 1533-4023
pISSN - 0160-2446
DOI - 10.1097/00005344-199301000-00017
Subject(s) - clonidine , bradycardia , midbrain , anatomy , heart rate , circulatory system , phenylephrine , norepinephrine , medicine , baroreflex , endocrinology , anesthesia , chemistry , blood pressure , dopamine , central nervous system
We examined the contribution of the ascending noradrenergic (NA) projections to the circulatory effects of intracisternal (i.c.) administration of clonidine and alpha-methyldopa (alpha-MD) in conscious rabbits. We compared the effects of combined dorsal and ventral NA fibre bundle lesions with those of individual bundle lesions. Local microinjection of 6-hydroxydopamine (6-OHDA) bilaterally into both NA fibre bundles in the midbrain produced marked reduction in norepinephrine (NE) after 4 weeks in all forebrain regions examined, but dopamine concentrations generally were not affected. The decreases in mean arterial pressure (MAP) and heart rate (HR) to i.c. injections of clonidine in animals with forebrain NE depletion were similar to those observed in vehicle-injected animals. In contrast, the normal decrease in HR produced by alpha-MD was abolished in rabbits with lesions of both the dorsal and ventral NA bundle (8% of control) and markedly reduced in rabbits with lesions of only the ventral bundle (33% of control). Lesions of the dorsal bundle alone produced a modest attenuation of bradycardia (62% of control). The effects of the lesions were not observed in sinoaortically denervated (SAD) rabbits, suggesting that the main component of the bradycardia affected was baroreflex vagal facilitation. The effects on the hypotension produced by alpha-MD were only slight.(ABSTRACT TRUNCATED AT 250 WORDS)