Open AccessBasal and Isoprenaline-Stimulated cAMP Content in Failing Versus Nonfailing Human Cardiac Preparations
Author(s) -
Wiebke Danielsen,
Heiko von der Leyen,
Wilfried Meyer,
Joachim Neumann,
Wilhelm Schmitz,
Hasso Scholz,
Jutta Starbatty,
Birgitt Stein,
Volker Döring,
P. Kalmár
Publication year - 1989
Publication title -
journal of cardiovascular pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.762
H-Index - 100
eISSN - 1533-4023
pISSN - 0160-2446
DOI - 10.1097/00005344-198907000-00026
Subject(s) - isoprenaline , medicine , contraction (grammar) , basal (medicine) , endocrinology , cardiology , heart failure , stimulation , insulin
We measured force of contraction and cAMP content in human isolated electrically driven right ventricular trabeculae carneae with and without the addition of isoprenaline (0.2 microM). Basal cAMP content was approximately 200% higher in preparations from nonfailing hearts than from hearts with end-stage myocardial failure. Isoprenaline was less effective in increasing force of contraction in failing (by approximately 100%) than in nonfailing cardiac preparations (by approximately 500%). With isoprenaline, cAMP content was approximately 50% lower in failing than in nonfailing preparations. We conclude that the reduced increase in force of contraction of failing human cardiac preparations with isoprenaline added may be causally related to an inadequately increased cAMP content.