Open AccessMolecular Mechanism of Endothelin-1 Action on Aortic Cells
Author(s) -
Van Renterghem C,
Paul Vigne,
Jacques Barhanin,
Annie Schmid-Alliana,
Christian Frelin,
M. Lazdunski
Publication year - 1989
Publication title -
journal of cardiovascular pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.762
H-Index - 100
eISSN - 1533-4023
pISSN - 0160-2446
DOI - 10.1097/00005344-198900135-00051
Subject(s) - depolarization , biophysics , mechanism of action , chemistry , phosphatidylinositol , endothelin receptor , endothelin 1 , microbiology and biotechnology , medicine , biochemistry , biology , signal transduction , in vitro , receptor
The vasoconstricting action of endothelin-1 (ET-1) is partly mediated by voltage-dependent L-type Ca2+ channels. Activation of the Ca2+ channels is indirect. ET-1 action involves (i) the hydrolysis of phosphatidylinositol and the release of Ca2+ from internal stores and (ii) the opening of a nonselective cation channel in the plasma membrane. The resulting depolarization triggers the activity of L-type Ca2+ channels.