Open AccessHemodynamic Effects of ICI 118.587 (Corwin) in Patients with Mild Cardiac Failure After Myocardial Infarction
Author(s) -
Gilbert Svensson,
Nina Rehnqvist,
A. Sjögren,
Leif Erhardt
Publication year - 1985
Publication title -
journal of cardiovascular pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.762
H-Index - 100
eISSN - 1533-4023
pISSN - 0160-2446
DOI - 10.1097/00005344-198501000-00016
Subject(s) - hemodynamics , medicine , cardiology , myocardial infarction , heart failure , cardiac function curve , cardiac output , placebo , anesthesia , alternative medicine , pathology
The aim of this study was to compare the effects of intravenous ICI 118.587 (Corwin), a new cardioselective partial beta-agonist, and placebo given q. 12 h for 4 consecutive days, with invasive and noninvasive methods. Twelve patients with mild to moderate cardiac failure after a myocardial infarction were studied. We could not show any significant effect of Corwin on hemodynamics, systolic time intervals, heart rates, or blood pressures. We conclude that Corwin does not affect left ventricular function, as measured by hemodynamics and systolic time intervals, in the immediate postinfarction period in patients with mild to moderate heart failure.