Open AccessThe Acute Antihypertensive Effect of Ketanserin Increases with Age
Author(s) -
J. De Crée,
M. Hoing,
Marc De Ryck,
J Symoens
Publication year - 1985
Publication title -
journal of cardiovascular pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.762
H-Index - 100
eISSN - 1533-4023
pISSN - 0160-2446
DOI - 10.1097/00005344-198500077-00037
Subject(s) - ketanserin , blood pressure , medicine , cardiology , diastole , anesthesia , serotonin , 5 ht receptor , receptor
The relationship between the acute blood pressure lowering effect of ketanserin with age was investigated in 57 patients ranging from 25 to 90 years (mean 61 years). There was a highly significant correlation between the degree of reduction of systolic and diastolic blood pressure and age, independent of the starting blood pressure. The fact that the acute blood pressure-lowering effect of ketanserin increases with age may suggest a role for serotonin in blood pressure regulation, particularly in elderly patients.