Open AccessSerotonergic Mechanisms in Isolated Human Peripheral Arteries and Veins
Author(s) -
Birgitta Arneklo-Nobin,
Anders Nobin,
Christer Owman,
K. Törnebrandt
Publication year - 1985
Publication title -
journal of cardiovascular pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.762
H-Index - 100
eISSN - 1533-4023
pISSN - 0160-2446
DOI - 10.1097/00005344-198500077-00016
Subject(s) - ketanserin , serotonin , serotonergic , mesenteric arteries , contraction (grammar) , blood vessel , medicine , epinephrine , norepinephrine , endocrinology , anatomy , 5 ht receptor , chemistry , artery , receptor , dopamine
Isolated arteries and veins from the hand and mesentery of healthy human subjects were studied in vitro. Serotonin caused contraction with an intrinsic activity approximately equal to that of norepinephrine and epinephrine in mesenteric and hand arteries and veins. Ketanserin inhibited the response to serotonin in a competitive, probably partly irreversible manner in the mesenteric vessels and the hand arteries. In the hand veins, ketanserin counteracted the serotonin-induced contraction in a noncompetitive way.