Open AccessPlatelet Serotonin and Blood Tryptophan in Spontaneously Hypertensive and Normotensive Wistar–Kyoto Rats
Author(s) -
Pascale Guicheney,
Maryvonne Baudouin-Legros,
JeanPierre Garnier,
P Roques,
C Dreux,
P Meyer
Publication year - 1985
Publication title -
journal of cardiovascular pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.762
H-Index - 100
eISSN - 1533-4023
pISSN - 0160-2446
DOI - 10.1097/00005344-198500077-00004
Subject(s) - serotonin , platelet , medicine , tryptophan , endocrinology , pharmacology , chemistry , receptor , biochemistry , amino acid
The number of platelets and their content in serotonin (5-HT) were determined in 12-week-old spontaneously hypertensive rats (SHR) and stroke-prone SHR (SHRSP) and in normotensive Wistar-Kyoto rats (WKY). Spontaneously hypertensive rats had 49% more platelets and a 65% higher platelet 5-HT circulating pool than SHRSP and WKY. An increased synthesis of 5-HT by enterochromaffin cells in SHR is suggested by the lower level of plasma total and albumin-bound tryptophan and by the higher free/bound tryptophan ratio found in those rats, as compared with WKY. In SHRSP, a decrease of platelet survival time was reported, associated to an increased platelet production. This would explain the absence of variation of platelet number and 5-HT content.