Open AccessNorepinephrine-induced Intracellular Ca2+ Release from Vascular Smooth Muscle
Author(s) -
P. Leijten,
Kaname Saida,
C. van Breemen
Publication year - 1985
Publication title -
journal of cardiovascular pharmacology
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.762
H-Index - 100
eISSN - 1533-4023
pISSN - 0160-2446
DOI - 10.1097/00005344-198500076-00007
Subject(s) - intracellular , myofilament , vascular smooth muscle , norepinephrine , biophysics , aorta , chemistry , medicine , smooth muscle , endocrinology , biology , biochemistry , actin , dopamine
In rabbit aorta and superior mesenteric artery, application of NE causes release of Ca2+ from an intracellular Ca2+ store, probably SR. The amount of released Ca2+ is sufficient to activate the myofilaments submaximally. It is suggested that NE mediates Ca2+ release by a rapid increase in the free Ca2+ concentration near the SR (Ca2+-induced Ca2+ release). The uptake of Ca2+ into the store and the Ca2+-induced Ca2+ release is modulated by c-AMP.