Open AccessCell Membrane Responsiveness and Excitation-Contraction Coupling in Smooth Muscle
Author(s) -
Rik Casteels,
Guillaume Droogmans
Publication year - 1984
Publication title -
journal of cardiovascular pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.762
H-Index - 100
eISSN - 1533-4023
pISSN - 0160-2446
DOI - 10.1097/00005344-198406002-00004
Subject(s) - endoplasmic reticulum , excitation–contraction coupling , contraction (grammar) , cytoplasm , biophysics , membrane , myocyte , smooth muscle , membrane potential , coupling (piping) , chemistry , cell , cell membrane , muscle contraction , receptor , microbiology and biotechnology , medicine , anatomy , endocrinology , biology , materials science , biochemistry , metallurgy
In this study of the excitation-contraction coupling in arterial smooth-muscle cells, the relations between changes of the membrane potential, force development, and 45Ca exchange have been investigated. It is proposed that the cell membrane plays a primary role by regulating the Ca entry into smooth-muscle cells and by extruding the excess cytoplasmic Ca. The possible relation between the receptor-operated channels and the sarcoplasmic reticulum has been discussed, and the peculiar differences between exogenous noradrenaline and noradrenaline released from the nerve terminals have been described.