Open AccessMethyclothiazide Attenuates Salt-Induced Hypertension Without Affecting Sympathetic Responsiveness in Dahl Rats
Author(s) -
Susumu Sasaki,
Ruben D. Buñag
Publication year - 1983
Publication title -
journal of cardiovascular pharmacology
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.762
H-Index - 100
eISSN - 1533-4023
pISSN - 0160-2446
DOI - 10.1097/00005344-198305000-00006
Subject(s) - weanling , vasopressin , endocrinology , medicine , blood pressure , norepinephrine , heart rate , sympathetic nervous system , stimulation , hypothalamus , dopamine
Methyclothiazide added for 7 weeks to the drinking water of weanling Dahl rats attenuated development of hypertension in salt-sensitive (DS) rats, but did not affect blood pressure in salt-resistant (DR) ones. There were no appreciable effects on heart rate, body weight, or sympathetic nerve activity. Cardiovascular responses to electrical stimulation of the ventromedial hypothalamus, or to intravenous injections of norepinephrine, tyramine, or vasopressin, were likewise unaffected. These results indicate that the antihypertensive effect of methyclothiazide in DS rats does not depend on sympathetic inhibition.