Open AccessNew Developments in α-Adrenoreceptor Drugs for the Treatment of Hypertension
Author(s) -
William J. Louis,
Roger J. Summers,
M. K. Dy,
B. Jarrott
Publication year - 1982
Publication title -
journal of cardiovascular pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.762
H-Index - 100
eISSN - 1533-4023
pISSN - 0160-2446
DOI - 10.1097/00005344-198200041-00033
Subject(s) - clonidine , alpha (finance) , pharmacology , chemistry , alpha 2 adrenergic receptor , receptor , agonist , adrenergic receptor , brainstem , blood pressure , kidney , sympatholytics , endocrinology , medicine , biochemistry , construct validity , nursing , patient satisfaction
The alpha 1- and alpha 2-adrenoreceptor types are defined in terms of the selective binding of radioligands and their displacement from membrane preparations by a range of agonists and antagonists. Their distribution is described in brain, kidney, heart, and peripheral blood vessels. A group of centrally acting clonidine-like drugs are classified in terms of their selectivity for the alpha 2-adrenoreceptors, and it is suggested that differences between alpha-adrenoreceptors in various tissues may allow development of highly selective alpha 2-adrenoreceptor agonists for specific tissue sites such as the juxtaglomerular cells and brainstem nuclei controlling blood pressure. It is further suggested that the aim of treatment with such compounds is to modulate adrenergic activity while retaining normal homeostatic mechanisms. For this purpose, competitive agonists and antagonists are preferable to compounds which bind irreversibly to the receptor.