Open AccessPlasma Markers of Platelet Activation in Cystic Fibrosis Liver and Lung Disease
Author(s) -
Kathleen B. Schwarz,
J Rosensweig,
Savitri Sharma,
Lawrence Jones,
M Durant,
Carol Potter,
Michael R. Narkewicz
Publication year - 2003
Publication title -
journal of pediatric gastroenterology and nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.206
H-Index - 131
eISSN - 1536-4801
pISSN - 0277-2116
DOI - 10.1097/00005176-200308000-00019
Subject(s) - medicine , cystic fibrosis , platelet factor 4 , platelet activation , liver disease , platelet , immunology
Transforming growth factor beta 1 (TGFbeta1) is a major fibrogenic cytokine, the expression of which is increased in the livers of children with cystic fibrosis liver disease (CFLD) and in the bronchoalveolar lavage fluid of patients with cystic fibrosis pulmonary disease (CFPD). The purpose of our study was to investigate the usefulness of plasma TGFbeta1 as a noninvasive marker of CFLD and CFPD, or both and to investigate the contribution of platelet-derived TGFbeta1 to plasma TGFbeta1 by correlating the latter with platelet factor 4 (PF4).