Open AccessEfficacy of Long-Term Treatment With Thalidomide in Children and Young Adults With Crohn Disease: Preliminary Results
Author(s) -
Sergio Facchini,
M. Candusso,
Stefano Martelossi,
Mario Liubich,
Enrico Panfili,
Alessandro Ventura
Publication year - 2001
Publication title -
journal of pediatric gastroenterology and nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.206
H-Index - 131
eISSN - 1536-4801
pISSN - 0277-2116
DOI - 10.1097/00005176-200102000-00016
Subject(s) - medicine , thalidomide , crohn's disease , proinflammatory cytokine , inflammatory bowel disease , refractory (planetary science) , gastroenterology , disease , surgery , inflammation , physics , astrobiology , multiple myeloma
Several proinflammatory cytokines are involved in the pathogenesis of inflammatory bowel diseases. A significant role has been given to tumor necrosis factor alpha (TNF-alpha) as a guide proinflammatory cytokine. Thalidomide selectively reduces TNF-alpha production by inflammatory cells. The aim of the study was to assess the efficacy of thalidomide to induce and maintain remission in refractory Crohn disease.