Open AccessObjective Ranking of Fibrosis in Standard Histologic Sections of Human Neonatal Liver: Applicability to α1-Antitrypsin Deficiency
Author(s) -
E Moustafellos,
Marta Illueca,
Helen Remotti,
Peter A. M. Auld,
Hartmut M. HanauskeAbel
Publication year - 2000
Publication title -
journal of pediatric gastroenterology and nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.206
H-Index - 131
eISSN - 1536-4801
pISSN - 0277-2116
DOI - 10.1097/00005176-200005000-00008
Subject(s) - medicine , fibrosis , liver biopsy , biopsy , pathology , liver disease , hepatic fibrosis , gastroenterology
The etiologic heterogeneity of fibrotic liver disease has resulted in the formulation of diverse, often disease-specific, classification systems for biopsy assessment, based on tissue morphology and staining. Their qualitative nature and observer dependency remain a concern, and no classification exists for several significant conditions--for example, alpha1-antitrypsin deficiency (alpha1-ATD). The authors propose a disease- and morphology-independent numeric ranking system to objectively quantify fibrosis in a standard histologic section, based on its content of protein amino acids. This PNC system is applied to two cases of alpha1-ATD liver fibrosis.