Open AccessDown Syndrome and Celiac Disease
Author(s) -
Ulf Jansson,
Christer Johansson
Publication year - 1995
Publication title -
journal of pediatric gastroenterology and nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.206
H-Index - 131
eISSN - 1536-4801
pISSN - 0277-2116
DOI - 10.1097/00005176-199511000-00012
Subject(s) - medicine , villous atrophy , down syndrome , disease , gastroenterology , atrophy , diabetes mellitus , coeliac disease , biopsy , intestinal malabsorption , immunopathology , endocrinology , psychiatry
Down syndrome is associated with immune-related disorders such as hypothyroidism, insulin-dependent diabetes mellitus, and celiac disease. In this study we determined antigliadin antibodies (AGA) in 54 patients with Down syndrome; 22 had AGA values above the cutoff limit. Nineteen patients underwent intestinal biopsy, and total or subtotal villous atrophy was found in nine. There was a total of 65 patients with Down syndrome in our area of southern Sweden; two were already known to have celiac disease. The minimum prevalence of celiac disease in Down syndrome in this area in southern Sweden was 11 of 65 or 16.9%.