Open AccessVascular Compromise Prior to Intestinal Manifestations of Crohnʼs Disease in a 14-Year-Old Girl
Author(s) -
Ruurd M. van Elburg,
Eric L. Henar,
C. M. A. Bijleveld,
Ted R. Prins,
H. S. A. Heymans
Publication year - 1992
Publication title -
journal of pediatric gastroenterology and nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.206
H-Index - 131
eISSN - 1536-4801
pISSN - 0277-2116
DOI - 10.1097/00005176-199201000-00018
Subject(s) - medicine , crohn's disease , disease , etiology , vascular disease , arteritis , bowel infarction , pathology , takayasu's arteritis , vasculitis , gastroenterology
Vascular manifestations as extraintestinal symptoms of Crohn's disease are rare and only occasionally reported in children. A 14-year-old girl with vascular compromise prior to intestinal manifestations of Crohn's disease is described. The vascular symptoms were due to segmental narrowing of several major arteries as shown by angiography. This kind of vascular involvement in our patient is different from the pattern described in Crohn's disease and resembles Takayasu's disease. Recently, it has been suggested that Crohn's disease could be mediated by multifocal gastrointestinal infarction due to chronic focal mesenteric arteritis at the level of the muscularis propria of the gut. In Takayasu's disease, a granulomatous inflammation of the vasa vasorum of affected vessels is frequently found. An intramural arteritis, granulomatous in nature, could be the common pathway in both Crohn's and Takayasu's diseases. Until the etiologies of both diseases are uncovered, the interrelation between them will remain subject to speculation.