Open AccessHypertransaminasemia as the First Symptom in Infant Celiac Disease
Author(s) -
Salvatore Leonardi,
G Bottaro,
R Patanè,
Salvatore Musumeci
Publication year - 1990
Publication title -
journal of pediatric gastroenterology and nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.206
H-Index - 131
eISSN - 1536-4801
pISSN - 0277-2116
DOI - 10.1097/00005176-199010000-00021
Subject(s) - medicine , gliadin , gastroenterology , disease , gluten , antibody , immunoglobulin a , coeliac disease , gluten free , intestinal mucosa , immunopathology , liver disease , immunology , pathology , immunoglobulin g
Two infants admitted for evaluation of hypertransaminasemia had high levels of anti-gliadin IgA and IgG antibodies and histological changes of the duodenal mucosa typical of celiac disease. Although the cause of the liver involvement could not be exactly identified, both the hypertransaminasemia and the histological changes of the mucosa disappeared after a short period of gluten-free diet. Even though two cases are not enough for definite conclusions, the authors suggest that an unexplained increase in transaminases would require an evaluation for celiac disease.