Open AccessTin-Protoporphyrin Inhibits Carbon Monoxide Production in Adult Male Wistar Rats with Common Bile Duct Ligation
Author(s) -
James J. Mcmillan,
Hendrik J. Vreman,
Daavid K. Stevenson
Publication year - 1987
Publication title -
journal of pediatric gastroenterology and nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.206
H-Index - 131
eISSN - 1536-4801
pISSN - 0277-2116
DOI - 10.1097/00005176-198709000-00024
Subject(s) - bilirubin , medicine , saline , endocrinology , protoporphyrin , ligature , jaundice , biochemistry , chemistry , porphyrin
The excretion rate of CO (VeCO), an index of total bilirubin production, and the total plasma bilirubin level are significantly elevated by 72 h after ligation of the common bile duct in adult male Wistar rats. At 72 and 96 h, rats prepared in this manner were subcutaneously injected with 50 mumol/kg body weight of tin-protoporphyrin IX (TP) (n = 5) or saline (n = 6). At 120 h after surgery, the VeCO had fallen from the pretreatment level in the TP-treated animals by 22% (P less than 0.025) compared with no significant change in the saline-treated controls. The plasma total bilirubin level of the experimental animals had also declined by 32% (p less than 0.0005) compared with their pretreatment level. The hyperbilirubinemia of the saline-treated controls was not significantly modified. These results suggest that TP reduces bilirubin production and plasma total bilirubin levels in adult rats with surgically created obstructive jaundice.