Open AccessEffects of Anticonvulsive Drugs on the Activity of Gammaglutamyltransferase and Aminotransferases in Serum
Author(s) -
J. A. Deutsch,
Gerhard Fritsch,
J Gölles,
Semmelrock Hj
Publication year - 1986
Publication title -
journal of pediatric gastroenterology and nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.206
H-Index - 131
eISSN - 1536-4801
pISSN - 0277-2116
DOI - 10.1097/00005176-198607000-00006
Subject(s) - primidone , phenobarbital , medicine , valproic acid , phenytoin , alanine aminotransferase , pharmacology , gamma glutamyltransferase , epilepsy , liver enzyme , liver disease , enzyme inducer , anticonvulsant , drug , enzyme , endocrinology , biochemistry , biology , psychiatry
A cross-sectional study was performed to define patients at risk of developing liver disease due to long-term treatment with anticonvulsive drugs. The activities of gamma-glutamyltransferase, aspartate aminotransferase, and alanine aminotransferase and the concentrations of primidone, phenobarbital, phenytoin, and valproic acid in serum were estimated. Epileptic children before therapy were used as controls. The results indicated enzyme induction due to phenobarbital and both enzyme induction and liver cell damage or plasma membrane leakage due to phenytoin. Gamma-glutamyltransferase may be an early indicator of liver disease due to valproic acid.