Open Accessγ-Glutamyl Transpeptidase Activity and Its Serial Measurement in Differentiation Between Extrahepatic Biliary Atresia and Neonatal Hepatitis
Author(s) -
K. P. Fung,
S. P. Lau
Publication year - 1985
Publication title -
journal of pediatric gastroenterology and nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.206
H-Index - 131
eISSN - 1536-4801
pISSN - 0277-2116
DOI - 10.1097/00005176-198504000-00009
Subject(s) - medicine , extrahepatic biliary atresia , neonatal hepatitis , biliary atresia , gastroenterology , atresia , differential diagnosis , hepatitis , extrahepatic bile ducts , liver disease , liver function tests , jaundice , pathology , liver transplantation , bile duct , transplantation
The liver functions of 17 babies with extrahepatic biliary atresia (EHBA) and 19 babies with neonatal hepatitis (NNH) were analyzed. The serum gamma-glutamyl transpeptidase (GGTP) level and its rate of rise were significantly higher in the EHBA group. Both cross-sectional and longitudinal studies showed a positive correlation between the GGTP activity and the duration of the disease. The diagnostic accuracy is 79% for EHBA and 95% for NNH. It is suggested that GGTP and its rate of rise are the most important biochemical parameters in the differential diagnosis of these two diseases.