Open AccessCell-Mediated Immunity in Children with Chronic Cholestasis
Author(s) -
Giuseppe Maggiore,
Costantino De Giacomo,
M. S. Scotta,
Salvatore Siena,
Rita Maccario,
Antonella Vitiello
Publication year - 1982
Publication title -
journal of pediatric gastroenterology and nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.206
H-Index - 131
eISSN - 1536-4801
pISSN - 0277-2116
DOI - 10.1097/00005176-198201030-00019
Subject(s) - cholestasis , medicine , immunity , gastroenterology , bile acid , immune system , cellular immunity , immunology
Cell-mediated immune response was evaluated in 14 children with long-lasting intra- or extrahepatic cholestasis. Cell-mediated immunity was clearly depressed in children with intrahepatic cholestasis while children with extrahepatic biliary obstruction had a more modest and variable degree of impairment. This finding may be related to the longer duration of cholestasis and the higher total bile acid level in the intrahepatic compared to the extrahepatic group. In particular, in children with Byler disease, long-lasting, severe intrahepatic cholestasis was associated with depressed cell-mediated immunity and recurrent severe infections.