Open AccessSystolic and pulse blood pressures (but not diastolic blood pressure and serum cholesterol) are associated with alterations in carotid intima–media thickness in the moderately hypercholesterolaemic hypertensive patients of the Plaque Hypertension Lipid Lowering Italian Study
Author(s) -
Alberto Zanchetti,
Gaetano Crepaldi,
M. Gene Bond,
Giuseppe Gallus,
Fabrizio Veglia,
Alessandro Ventura,
Giuseppe Mancia,
Giovannella Baggio,
Lorena Sampieri,
P. Rubba,
S Collatina,
Elio Serrotti
Publication year - 2001
Publication title -
journal of hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.249
H-Index - 172
eISSN - 1473-5598
pISSN - 0263-6352
DOI - 10.1097/00004872-200101000-00011
Subject(s) - medicine , blood pressure , ambulatory blood pressure , cardiology , intima media thickness , pulse pressure , pravastatin , diastole , endocrinology , triglyceride , dipper , systolic hypertension , cholesterol , carotid arteries
The Plaque Hypertension Lipid Lowering Italian Study (PHYLLIS), is the first study in patients with hypertension (diastolic blood pressure (DBP) 95-115 mmHg; systolic blood pressure (SBP) 150-210 mmHg), moderate hypercholesterolaemia (LDL-cholesterol 4.14-5.17 mmol/l (160-200 mg/dl) and initial carotid artery alterations (maximum intima-media thickness (IMT) Tmax > or = 1.3 mm). The primary objective of PHYLLIS is investigating whether in these patients administration of an angiotensin converting enzyme inhibitor, fosinopril, and a statin, pravastatin, is more effective than administration of a diuretic and a lipid-lowering diet in retarding or regressing alterations in carotid IMT. While the study is in progress, baseline data are here reported to clarify the association of various risk factors with carotid IMT in these medium-high risk hypertensive patients.