Open AccessMacrophage Migration Inhibitory Factor in Uveitis
Author(s) -
Satoshi Kotake,
Nobuyoshi Kitaichi,
Shigeaki Ohno
Publication year - 2002
Publication title -
international ophthalmology clinics
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.431
H-Index - 41
eISSN - 1536-9617
pISSN - 0020-8167
DOI - 10.1097/00004397-200201000-00014
Subject(s) - macrophage migration inhibitory factor , uveitis , medicine , immunology , lymphokine , sarcoidosis , cytokine , vogt–koyanagi–harada disease , antigen
To summarize, we found that high levels of MIF were detected in the serum of uveitis patients with Behçet's disease, VKH disease, and sarcoidosis, as well as idiopathic iridocyclitis. In Behçet's disease and sarcoidosis, the MIF levels were higher in the active uveitis stage than in the inactive stage. Serum MIF increased after corticosteroid therapy in VKH disease. A high aqueous humor MIF concentration was detected at the onset of EAU. Finally, anti-MIF antibody suppressed EAU when administered in the early phase. MIF is thought to be an important cytokine in the pathogenesis of uveitis.