Open AccessContraction-Induced Myokine Production and Release: Is Skeletal Muscle an Endocrine Organ?
Author(s) -
Mark A. Febbraio,
Bente Klarlund Pedersen
Publication year - 2005
Publication title -
exercise and sport sciences reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.945
H-Index - 99
eISSN - 1538-3008
pISSN - 0091-6331
DOI - 10.1097/00003677-200507000-00003
Subject(s) - myokine , skeletal muscle , endocrine system , endocrinology , muscle contraction , medicine , biology , hormone
The concentration of plasma interleukin-6 (IL-6) increases during physical exercise, but until recently the cellular origin of this increase has been unknown. Recent work has identified that skeletal muscle is a major source of this increase and the release of IL-6 from muscle can mediate metabolic processes. IL-6 is, therefore, the first identified "myokine" released from muscle that can now be termed an endocrine organ.