Open AccessThe Effect of Exercise Training on Endothelial Function in Cardiovascular Disease in Humans
Author(s) -
Claudia Walther,
Stephan Gielen,
Rainer Hambrecht
Publication year - 2004
Publication title -
exercise and sport sciences reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.945
H-Index - 99
eISSN - 1538-3008
pISSN - 0091-6331
DOI - 10.1097/00003677-200410000-00002
Subject(s) - endothelial dysfunction , medicine , disease , nitric oxide , endothelium , cardiology , intervention (counseling) , bioinformatics , physical therapy , biology , psychiatry
Endothelial dysfunction occurs early in atherosclerosis in response to cardiovascular risk factors. The occurrence of endothelial dysfunction is primarily the result of reduced nitric oxide (NO) bioavailabilty. It represents an independent predictor of cardiovascular events and predicts the prognosis of the patient. Therefore, endothelial function has been identified as a target for therapeutic intervention. Regular exercise training is a nonpharmacological option to improve endothelial dysfunction in patients with cardiovascular disease by increasing NO bioavailability.