Open AccessGlycogen Synthase: Key Effect of Exercise on Insulin Action
Author(s) -
Christine Y. Christ-Roberts,
Lawrence J. Mandarino
Publication year - 2004
Publication title -
exercise and sport sciences reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.945
H-Index - 99
eISSN - 1538-3008
pISSN - 0091-6331
DOI - 10.1097/00003677-200407000-00003
Subject(s) - glut4 , insulin , endocrinology , medicine , glycogen synthase , glycogen , insulin receptor , glucose transporter , biology , chemistry , insulin resistance
Exercise improves insulin action in muscle, but the mechanisms are poorly characterized. Despite the notion that increased insulin signaling would accompany improved insulin sensitivity, this is not universally true. Increased activity or expression of other proteins seems to be more important. An increase in activity and expression of glycogen synthase and GLUT4 may be key to the effects of exercise.