Open AccessNeurogenesis of Excitation-Contraction Uncoupling in Aging Skeletal Muscle
Author(s) -
Anthony M. M. Payne,
Osvaldo Delbono
Publication year - 2004
Publication title -
exercise and sport sciences reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.945
H-Index - 99
eISSN - 1538-3008
pISSN - 0091-6331
DOI - 10.1097/00003677-200401000-00008
Subject(s) - skeletal muscle , contraction (grammar) , denervation , muscle contraction , neurogenesis , uncoupling protein , neuromuscular junction , biology , endocrinology , neuroscience , chemistry , microbiology and biotechnology , medicine , brown adipose tissue , obesity
Excitation-contraction (EC) uncoupling is a major cause of decreased muscle force generating capacity (specific force). However, the underlying mechanisms of EC uncoupling in muscle from aging mammals have not been characterized. We propose that impaired motor neuron function with aging leading to muscle denervation, a process probably initiated earlier than detected by in vitro morphologic techniques, results in EC uncoupling.