Open AccessMuscle Afferent???Pituitary Axis: A Novel Pathway for Modulating the Secretion of a Pituitary Growth Factor
Author(s) -
Gary E. McCall,
K. L. Gosselink,
A. J. Bigbee,
Roland R. Roy,
R. E. Grindeland,
V. Reggie Edgerton
Publication year - 2001
Publication title -
exercise and sport sciences reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.945
H-Index - 99
eISSN - 1538-3008
pISSN - 0091-6331
DOI - 10.1097/00003677-200110000-00006
Subject(s) - endocrinology , spaceflight , stimulus (psychology) , medicine , secretion , endocrine system , proprioception , pituitary gland , skeletal muscle , afferent , neuroscience , biology , psychology , hormone , engineering , psychotherapist , aerospace engineering
Evidence is presented for a novel muscle-neuro-endocrine pathway for modulating the secretion of an unidentified pituitary growth factor by proprioceptive input from skeletal muscle afferents. Exercise stimulates the release of this growth factor, whereas chronic unloading associated with bed rest or spaceflight abrogates the normal exercise stimulus.