Open AccessDoes Aging Adversely Affect Muscle Mitochondrial Function?
Author(s) -
Kevin R. Short,
K. Sreekumaran Nair
Publication year - 2001
Publication title -
exercise and sport sciences reviews
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.945
H-Index - 99
eISSN - 1538-3008
pISSN - 0091-6331
DOI - 10.1097/00003677-200107000-00006
Subject(s) - mitochondrial dna , oxidative phosphorylation , mitochondrion , oxidative stress , oxidative damage , affect (linguistics) , biology , function (biology) , skeletal muscle , muscle damage , microbiology and biotechnology , medicine , endocrinology , chemistry , biochemistry , gene , psychology , communication
Muscle oxidative function appears to decline with aging, and evidence suggests that this is related to reduced synthesis of mitochondrial and other muscle proteins. Causes for these events may include mtDNA damage or reduced mtDNA copy numbers, reduced oxidative enzyme activities and ATP production, and increased proton leak.