Open AccessTopical Administration of HSV gD-IL-2 DNA Is Highly Protective Against Murine Herpetic Stromal Keratitis
Author(s) -
Tomoyuki Inoue,
Yoshitsugu Inoue,
Kozaburo Hayashi,
Atsushi Yoshida,
Kohji Nishida,
Yoshikazu Shimomura,
Yukio Fujisawa,
Aki Aono,
Yasuo Tano
Publication year - 2002
Publication title -
cornea
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.274
H-Index - 117
eISSN - 1536-4798
pISSN - 0277-3740
DOI - 10.1097/00003226-200201000-00022
Subject(s) - keratitis , spleen , herpes simplex virus , neutralizing antibody , lymph , medicine , immunology , virology , cytotoxic t cell , cervical lymph nodes , antibody , systemic administration , dna vaccination , stromal cell , virus , immunization , biology , pathology , in vivo , in vitro , dermatology , biochemistry , microbiology and biotechnology , cancer , metastasis
To evaluate the immunopreventive effect of eyedrops that contain gD-IL-2 DNA (a chimeric gene of the glycoprotein D gene of herpes simplex virus type I (HSV-1) and human interleukin-2 (IL-2) on murine herpetic keratitis.