Open AccessEffect of Extracorporeal Membrane Oxygenation on Body Water Content and Distribution in Lambs
Author(s) -
Nadya J. Kazzi,
Connie A. Schwartz,
Steven B. Palder,
Grant C. Whittlesey,
M. D. Klein,
Yves W. Brans
Publication year - 1990
Publication title -
asaio transactions
Language(s) - English
Resource type - Journals
eISSN - 2375-0952
pISSN - 0889-7190
DOI - 10.1097/00002480-199010000-00007
Subject(s) - extracorporeal membrane oxygenation , body water , fluid compartments , extracellular fluid , dilution , extracorporeal , blood volume , chemistry , water content , anesthesia , dehydration , medicine , zoology , body weight , extracellular , biology , biochemistry , physics , geotechnical engineering , engineering , thermodynamics
Water content of the various body compartments were estimated immediately after beginning extracorporeal membrane oxygenation (ECMO), and daily thereafter for 3 days, in seven healthy 2-month-old lambs. Total body water, extracellular water, and plasma volume were estimated simultaneously by 18O, bromide, and T-1824 dilution, respectively. Volumes of intracellular water, interstitial water, blood, and red cells were calculated from the experimental estimates. No statistically significant changes occurred in the water content of the various body compartments in relation to duration of ECMO. The data suggest that water retention, clinically noted in human neonates treated with ECMO for persistent pulmonary hypertension, may be related to the primary disease process and/or its medical management, rather than to ECMO.