Open AccessAluminum Toxicity and Albumin
Author(s) -
Anna T. Kelly,
Billie Lou Short,
T. C. Rains,
Jeffrey C. May,
Joseph J. Progar
Publication year - 1989
Publication title -
asaio transactions
Language(s) - English
Resource type - Journals
eISSN - 2375-0952
pISSN - 0889-7190
DOI - 10.1097/00002480-198907000-00164
Subject(s) - albumin , extracorporeal membrane oxygenation , chemistry , membrane oxygenator , aluminium , chromatography , materials science , metallurgy , biochemistry , medicine , surgery
During a study of priming solutions for extracorporeal membrane oxygenation (ECMO) in the intensive care nursery, it was discovered that those solutions using certain brands of 25% albumin contained aluminum levels within the toxic range. When the brand was changed to a brand known to have a lower aluminum (Al) content, a marked drop in priming solution Al levels was measured. The heat exchanger was examined as a possible source of soluble Al. No evidence of elevated Al levels was found in fluids perfusing this heat exchanger when compared with a stainless steel heat exchanger. The Al content of various blood products was evaluated along with various brands of 5% albumin and 25% albumin.