Open AccessQuantitation of Platelet Loss with Indium-111 Labeled Platelets in a Hollow-Fiber Membrane Oxygenator and Arterial Filter During Extracorporeal Circulation in a Pig Model
Author(s) -
George M. Palatianos,
Mrinal K. Dewanjee,
Ronald P. Robinson,
Staovak,
Pijush K. Dewanjee,
Mansur Kapadvanjwala,
Limin Hsu,
George N. Sfakianakis,
Gerard A. Kaiser
Publication year - 1989
Publication title -
asaio transactions
Language(s) - English
Resource type - Journals
eISSN - 2375-0952
pISSN - 0889-7190
DOI - 10.1097/00002480-198907000-00162
Subject(s) - platelet , extracorporeal circulation , oxygenator , membrane oxygenator , extracorporeal membrane oxygenation , materials science , medicine , biomedical engineering , cardiology , cardiopulmonary bypass
Platelet consumption in a hollow-fiber membrane oxygenator (HFMO) and arterial filter (AF) during cardiopulmonary bypass (CPB) was quantified in five pigs using Indium-111 labeled autologous platelets. Platelet labeling was performed 20-24 hours before CPB. After general endotracheal anesthesia, the pigs were systemically heparinized and were placed on CPB via a median sternotomy. After 3 hours of CPB, radioactivity was quantified with a gamma camera and an ionization chamber. The percent of injected dose (mean +/- SD) was 0.79 +/- 0.45 in the HFMO, 2.52 +/- 0.93 in AF, 4.3 +/- 1.2 in blood loss during CPB. Platelet consumption in HFMO during CPB was lower than in bubble oxygenators (19%) or silicone membrane oxygenators (12%) as observed in previous studies.