Open AccessImprovement of Peripheral Circulation by Low Density Lipoprotein Adsorption
Author(s) -
Tetsuzo Agishi,
Yuri Kitano,
Toshihide Suzuki,
Asako Miura,
Jun Murakami,
H Minagawa,
Kanako Ban
Publication year - 1989
Publication title -
asaio transactions
Language(s) - English
Resource type - Journals
eISSN - 2375-0952
pISSN - 0889-7190
DOI - 10.1097/00002480-198907000-00057
Subject(s) - ldl apheresis , extracorporeal circulation , apheresis , concomitant , peripheral , intermittent claudication , medicine , low density lipoprotein , adsorption , lipoprotein , chemistry , cardiology , surgery , cholesterol , vascular disease , organic chemistry , arterial disease , platelet
Low density lipoprotein (LDL) was removed by repeated extracorporeal adsorption with a dextran sulphate cellulose column in 5 patients with clinical signs of poor peripheral circulation. The LDL apheresis was continued for 2 to 10 months, and symptoms such as cold or "heavy" legs, or intermittent claudication rapidly improved early in the treatment course in all 5 patients. Clearing of mentation occurred in 3, and recovery of kidney function was seen in 1 patient. These improvements occurred concomitant with a reduction in LDL level.