Open AccessHIV-1 Tat inhibits neprilysin and elevates amyloid β
Author(s) -
Hans Rempel,
Lynn Pulliam
Publication year - 2005
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/00002030-200501280-00004
Subject(s) - neprilysin , human brain , biology , immunostaining , medicine , immunology , enzyme , immunohistochemistry , biochemistry , neuroscience
Aging is a risk factor for amyloid beta (Abeta) accumulation and dementia. Since highly active antiretroviral therapies have effectively lengthened the life expectancy of individuals infected with HIV-1, we investigated the affect of HIV-1 Tat, a viral transactivating transcription factor, on Abeta degradation in the brain by neprilysin (NEP), a neuronal endopeptidase.