Open AccessPredicted genotypic resistance to the novel entry inhibitor, BMS-378806, among HIV-1 isolates of subtypes A to G
Author(s) -
Penny L. Moore,
Tonie Cilliers,
Lynn Morris
Publication year - 2004
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/00002030-200411190-00015
Subject(s) - genotype , virology , biology , human immunodeficiency virus (hiv) , virus , drug resistance , genetics , gene
BMS-378806 targets virus entry by inhibiting the binding of HIV-1 gp120 to the CD4 receptor. Env sequences (n = 1226) of subtypes A-G were analysed to determine the frequency of mutations associated with resistance to BMS-378806. In line with reported sensitivity data, background genotypic resistance to BMS-378806 among non-B HIV-1 viruses was found to be higher than in subtype B. These data suggest that BMS-378806 may have reduced efficacy against non-B viruses.