Open AccessTetanus vaccination with IL-2 during highly active antiretroviral therapy induces sustained and pronounced specific CD4 T-cell responses
Author(s) -
Gareth Hardy,
Nesrina Imami,
Ann Sullivan,
Mark Nelson,
Brian Gazzard,
Frances Gotch
Publication year - 2004
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/00002030-200411050-00014
Subject(s) - tetanus , vaccination , medicine , immunology , antiretroviral therapy , virology , lentivirus , viral disease , human immunodeficiency virus (hiv) , viral load
HIV-1 infection results in profound dysfunction of the CD4 T-cell population. Although highly active antiretroviral therapy allows the reconstitution of CD4 T-cell numbers, functional abnormalities remain, including inadequate responses to vaccination. IL-2 increases CD4 T-cell numbers and function. We report the effects of IL-2 given with tetanus vaccination in two patients in a larger immunotherapy study. In one case IL-2 induced sustained responses, which may have been caused by the timing of IL-2 with vaccination.